IZZIE'S ANGER AT THE PHILANDERING ALEX GETS THE BEST OF HER, ON ABC'S "GREY'S ANATOMY"

Rosanna Arquette Guest Stars

"Owner of a Lonely Heart" - Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson, on "Grey's Anatomy," SUNDAY, DECEMBER 4 (10:01-11:00 p.m., ET) on the ABC Television Network.

"Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Isaiah Washington as Preston Burke, Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O'Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, and Kate Walsh as Addison Shepherd.

Guest starring is Rosanna Arquette as Constance Ferguson. Other guest cast TBA.

"Owner of a Lonely Heart" was written by Mark Wilding and was directed by Dan Minahan.

From: ABC Medianet

This episode looks so good!

Dude! I know...did you see last weeks eppy? I can't wait to see what she says to him tonight!

Ooooh... the elevator scene... I bet she was clenching her fist, trying to resist the urge to deck the nurse... haha...